Unfortunately, I don't much like Andie McDowell, having seen her be quite the snoot on Letterman (I think it was). So I think Bill Murray's character should get a better reward for his perseverance. Nominations? It should be a female character in a movie. I'll start with these:
1. Barbara Bel Geddes in Vertigo
2. Sigourney Weaver in Alien (or sequel)
3. Rosalind Russell in His Girl Friday
4. Olympia Dukakis in Tales of the City